Doctor's Best SAMe is proven to enhance mood and promote cognitive healthSAMe is essential for the healthy metabolism of the major brain transmitters dopamine, serotonin and norepinephrineSAMe has been proven to promote joint comfort and mobility and supports liver health and detoxificationSAMe's effectiveness has been proven with 18 controlled human trials published over 40 yearsPharmaceutical grade, Non-GMO, Gluten Free, Vegan